Protein Info for b4219 in Escherichia coli BW25113

Name: msrA
Annotation: methionine sulfoxide reductase A (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00401: peptide-methionine (S)-S-oxide reductase
  • amino acids 44 to 199 (156 residues), 240.6 bits, E=4.4e-76
• PF01625: PMSR
  • amino acids 46 to 199 (154 residues), 218 bits, E=3.7e-69

Best Hits

Swiss-Prot: 100% identical to MSRA_ECO24: Peptide methionine sulfoxide reductase MsrA (msrA) from Escherichia coli O139:H28 (strain E24377A / ETEC)

KEGG orthology group: K07304, peptide-methionine (S)-S-oxide reductase [EC: 1.8.4.11] (inferred from 100% identity to eco:b4219)

MetaCyc: 100% identical to methionine sulfoxide reductase A (Escherichia coli K-12 substr. MG1655)
L-methionine (S)-S-oxide reductase. [EC: 1.8.4.13]; Peptide-methionine (S)-S-oxide reductase. [EC: 1.8.4.13, 1.8.4.11]

Predicted SEED Role

"Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11)" (EC 1.8.4.11)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.4.11 or 1.8.4.13

Sequence Analysis Tools

See P0A744 at UniProt or InterPro

Protein Sequence (212 amino acids)

>b4219 methionine sulfoxide reductase A (NCBI) (Escherichia coli BW25113)
MSLFDKKHLVSPADALPGRNTPMPVATLHAVNGHSMTNVPDGMEIAIFAMGCFWGVERLF
WQLPGVYSTAAGYTGGYTPNPTYREVCSGDTGHAEAVRIVYDPSVISYEQLLQVFWENHD
PAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAAMLAADDDRHITTEIANATPF
YYAEDDHQQYLHKNPYGYCGIGGIGVCLPPEA