Protein Info for b4178 in Escherichia coli BW25113

Name: yjeB
Annotation: predicted DNA-binding transcriptional regulator (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 141 TIGR00738: Rrf2 family protein" amino acids 1 to 128 (128 residues), 125 bits, see alignment E=9.3e-41 PF02082: Rrf2" amino acids 3 to 130 (128 residues), 129.4 bits, see alignment E=5e-42

Best Hits

Swiss-Prot: 100% identical to NSRR_ECO57: HTH-type transcriptional repressor NsrR (nsrR) from Escherichia coli O157:H7

KEGG orthology group: K13771, Rrf2 family transcriptional regulator, nitric oxide-sensitive transcriptional repressor (inferred from 100% identity to eco:b4178)

Predicted SEED Role

"Nitrite-sensitive transcriptional repressor NsrR" in subsystem Nitrosative stress or Oxidative stress or Rrf2 family transcriptional regulators

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0AF63 at UniProt or InterPro

Protein Sequence (141 amino acids)

>b4178 predicted DNA-binding transcriptional regulator (NCBI) (Escherichia coli BW25113)
MQLTSFTDYGLRALIYMASLPEGRMTSISEVTDVYGVSRNHMVKIINQLSRAGYVTAVRG
KNGGIRLGKPASAIRIGDVVRELEPLSLVNCSSEFCHITPACRLKQALSKAVQSFLTELD
NYTLADLVEENQPLYKLLLVE