Protein Info for b4115 in Escherichia coli BW25113

Name: adiC
Annotation: arginine:agmatin (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 41 to 61 (21 residues), see Phobius details amino acids 91 to 116 (26 residues), see Phobius details amino acids 122 to 142 (21 residues), see Phobius details amino acids 152 to 173 (22 residues), see Phobius details amino acids 193 to 217 (25 residues), see Phobius details amino acids 226 to 250 (25 residues), see Phobius details amino acids 274 to 296 (23 residues), see Phobius details amino acids 320 to 340 (21 residues), see Phobius details amino acids 352 to 375 (24 residues), see Phobius details amino acids 386 to 404 (19 residues), see Phobius details amino acids 410 to 428 (19 residues), see Phobius details PF13520: AA_permease_2" amino acids 11 to 403 (393 residues), 169.9 bits, see alignment E=9.5e-54 PF00324: AA_permease" amino acids 15 to 378 (364 residues), 113 bits, see alignment E=1.6e-36

Best Hits

Swiss-Prot: 100% identical to ADIC_SHIFL: Arginine/agmatine antiporter (adiC) from Shigella flexneri

KEGG orthology group: K03759, arginine:agmatine antiporter (inferred from 100% identity to eco:b4115)

MetaCyc: 100% identical to arginine:agmatine antiporter (Escherichia coli K-12 substr. MG1655)
RXN0-2162

Predicted SEED Role

"Arginine/agmatine antiporter" in subsystem Acid resistance mechanisms or Arginine and Ornithine Degradation or Polyamine Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P60061 at UniProt or InterPro

Protein Sequence (445 amino acids)

>b4115 arginine:agmatin (NCBI) (Escherichia coli BW25113)
MSSDADAHKVGLIPVTLMVSGNIMGSGVFLLPANLASTGGIAIYGWLVTIIGALGLSMVY
AKMSFLDPSPGGSYAYARRCFGPFLGYQTNVLYWLACWIGNIAMVVIGVGYLSYFFPILK
DPLVLTITCVVVLWIFVLLNIVGPKMITRVQAVATVLALIPIVGIAVFGWFWFRGETYMA
AWNVSGLGTFGAIQSTLNVTLWSFIGVESASVAAGVVKNPKRNVPIATIGGVLIAAVCYV
LSTTAIMGMIPNAALRVSASPFGDAARMALGDTAGAIVSFCAAAGCLGSLGGWTLLAGQT
AKAAADDGLFPPIFARVNKAGTPVAGLIIVGILMTIFQLSSISPNATKEFGLVSSVSVIF
TLVPYLYTCAALLLLGHGHFGKARPAYLAVTTIAFLYCIWAVVGSGAKEVMWSFVTLMVI
TAMYALNYNRLHKNPYPLDAPISKD