Protein Info for b4017 in Escherichia coli BW25113

Name: arpA
Annotation: regulator of acetyl CoA synthetase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 728 PF07906: Toxin_15" amino acids 121 to 379 (259 residues), 322.8 bits, see alignment E=2.3e-100

Best Hits

Swiss-Prot: 100% identical to ARPA_ECOLI: Ankyrin repeat protein A (arpA) from Escherichia coli (strain K12)

KEGG orthology group: K06867, (no description) (inferred from 100% identity to eco:b4017)

Predicted SEED Role

"Ankyrin-repeat protein A"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P23325 at UniProt or InterPro

Protein Sequence (728 amino acids)

>b4017 regulator of acetyl CoA synthetase (NCBI) (Escherichia coli BW25113)
MITRIPRSSFSANINNTAQTNEHQTLSELFYKELEDKFSGKELATPLLKSFSENCRQNGR
HIFSNKDFVIKFSTSVLQADKKEITIINKNENTTLTQTIAPIFEKYLMEILPQRSDTLDK
QELNLKSDRKEKEFPRIKLNGQCYFPGRPQNRIVCRHIAAQYINDIYQNVDYKPHQDDYS
SAEKFLTHFNKKCKNQTLALVSSRPEGRCVAACGDFGLVMKAYFDKMESNGISVMAAILL
VDNHALTVRLRIKNTTEGCTHYVVSVYDPNVTNDKIRIMSESKENIKHYSLMDFMNVDYS
LLKWSNDHVINQSVAIIPALPKEQLLMLKGSVDEITPPLSPATMNLLMAIGQNHQLTQLM
IQLQKMPELHRTEMLTAYNSINLPGLYLAINYGNADIVETIFNSLSETGYEGLLSKKNLM
HILEAKDKNGFSGLFLAISRKDKNVVTSILNALPKLAATHHLDNEQVYKFLSAKNRTSSH
VLYHVMANGDADMLKIVLNALPLLIRTCHLTKEQVLDLLKAKDFYGCPGLYLAMQNGHSD
IVKVILEALPSLAQEINISASDIVDLLTAKSLARDTGLFMAMQRGHMNVINTIFNALPTL
FNTFKFDKKNMKPLLLANNSNEYPGLFSAIQHKQQNVVETVYLALSDHARLFGFTAEDIM
DFWQHKAPQKYSAFELAFEFGHRVIAELILNTLNKMAESFGFTDNPRYIAEKNYMEALLK
KASPHTVR