Protein Info for b3580 in Escherichia coli BW25113

Name: lyxK
Annotation: L-xylulose kinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00370: FGGY_N
  • amino acids 4 to 250 (247 residues), 321.2 bits, E=4.8e-100
• PF02782: FGGY_C
  • amino acids 259 to 440 (182 residues), 74.9 bits, E=7.9e-25

Best Hits

Swiss-Prot: 100% identical to LYXK_ECOLI: L-xylulose/3-keto-L-gulonate kinase (lyx) from Escherichia coli (strain K12)

KEGG orthology group: K00880, L-xylulokinase [EC: 2.7.1.53] (inferred from 100% identity to eco:b3580)

MetaCyc: 100% identical to L-xylulose kinase (Escherichia coli K-12 substr. MG1655)
L-xylulokinase. [EC: 2.7.1.53]; RXN0-704 [EC: 2.7.1.53]

Predicted SEED Role

No annotation

MetaCyc Pathways

• L-ascorbate degradation II (bacterial, aerobic) (7/7 steps found)
• L-lyxose degradation (4/4 steps found)
• superpathway of pentose and pentitol degradation (18/42 steps found)

KEGG Metabolic Maps

• Ascorbate and aldarate metabolism
• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.53

Sequence Analysis Tools

See P37677 at UniProt or InterPro

Protein Sequence (498 amino acids)

>b3580 L-xylulose kinase (NCBI) (Escherichia coli BW25113)
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIR
ALLTHSGVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPE
KLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
SNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEA
SPTSSGNLEWFTAQWGEISFDEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
IELPQVEETGCFGAALAARVGTGVYHNFSEAQRDLRHPVRTLLPDMTAHQLYQKKYQRYQ
HLIAALQGFHARIKEHTL