Protein Info for b2992 in Escherichia coli BW25113

Name: hybE
Annotation: hydrogenase 2-specific chaperone (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 162 PF11939: NiFe-hyd_HybE" amino acids 12 to 155 (144 residues), 161.3 bits, see alignment E=8.3e-52 TIGR03993: [NiFe] hydrogenase assembly chaperone, HybE family" amino acids 16 to 153 (138 residues), 160 bits, see alignment E=1.7e-51

Best Hits

Swiss-Prot: 100% identical to HYBE_ECOL6: Hydrogenase-2 operon protein HybE (hybE) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: None (inferred from 100% identity to eco:b2992)

Predicted SEED Role

"Hydrogenase-2 operon protein hybE"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0AAN1 at UniProt or InterPro

Protein Sequence (162 amino acids)

>b2992 hydrogenase 2-specific chaperone (NCBI) (Escherichia coli BW25113)
MTEEIAGFQTSPKAQVQAAFEEIARRSMHDLSFLHPSMPVYVSDFTLFEGQWTGCVITPW
MLSAVIFPGPDQLWPLRKVSEKIGLQLPYGTMTFTVGELDGVSQYLSCSLMSPLSHSMSI
EEGQRLTDDCARMILSLPVTNPDVPHAGRRALLFGRRSGENA