Protein Info for b2965 in Escherichia coli BW25113
Name: speC
Annotation: ornithine decarboxylase isozyme (VIMSS)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to DCOR_ECOLI: Constitutive ornithine decarboxylase (speC) from Escherichia coli (strain K12)
KEGG orthology group: K01581, ornithine decarboxylase [EC: 4.1.1.17] (inferred from 100% identity to ecx:EcHS_A3126)MetaCyc: 100% identical to constitutive ornithine decarboxylase (Escherichia coli K-12 substr. MG1655)
Ornithine decarboxylase. [EC: 4.1.1.17]
Predicted SEED Role
"Ornithine decarboxylase (EC 4.1.1.17)" in subsystem Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.17)
MetaCyc Pathways
- superpathway of arginine and polyamine biosynthesis (16/17 steps found)
- superpathway of L-arginine and L-ornithine degradation (13/13 steps found)
- superpathway of ornithine degradation (8/8 steps found)
- superpathway of polyamine biosynthesis I (7/8 steps found)
- superpathway of putrescine biosynthesis (3/4 steps found)
- putrescine biosynthesis III (1/2 steps found)
- superpathway of polyamine biosynthesis II (4/8 steps found)
- superpathway of hyoscyamine (atropine) and scopolamine biosynthesis (3/16 steps found)
KEGG Metabolic Maps
- Arginine and proline metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Glutathione metabolism
- Urea cycle and metabolism of amino groups
Isozymes
Compare fitness of predicted isozymes for: 4.1.1.17
Use Curated BLAST to search for 4.1.1.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See P21169 at UniProt or InterPro
Protein Sequence (711 amino acids)
>b2965 ornithine decarboxylase isozyme (VIMSS) (Escherichia coli BW25113) MKSMNIAASSELVSRLSSHRRVVALGDTDFTDVAAVVITAADSRSGILALLKRTGFHLPV FLYSEHAVELPAGVTAVINGNEQQWLELESAACQYEENLLPPFYDTLTQYVEMGNSTFAC PGHQHGAFFKKHPAGRHFYDFFGENVFRADMCNADVKLGDLLIHEGSAKDAQKFAAKVFH ADKTYFVLNGTSAANKVVTNALLTRGDLVLFDRNNHKSNHHGALIQAGATPVYLEASRNP FGFIGGIDAHCFNEEYLRQQIRDVAPEKADLPRPYRLAIIQLGTYDGTVYNARQVIDTVG HLCDYILFDSAWVGYEQFIPMMADSSPLLLELNENDPGIFVTQSVHKQQAGFSQTSQIHK KDNHIRGQARFCPHKRLNNAFMLHASTSPFYPLFAALDVNAKIHEGESGRRLWAECVEIG IEARKAILARCKLFRPFIPPVVDGKLWQDYPTSVLASDRRFFSFEPGAKWHGFEGYAADQ YFVDPCKLLLTTPGIDAETGEYSDFGVPATILAHYLRENGIVPEKCDLNSILFLLTPAES HEKLAQLVAMLAQFEQHIEDDSPLVEVLPSVYNKYPVRYRDYTLRQLCQEMHDLYVSFDV KDLQKAMFRQQSFPSVVMNPQDAHSAYIRGDVELVRIRDAEGRIAAEGALPYPPGVLCVV PGEVWGGAVQRYFLALEEGVNLLPGFSPELQGVYSETDADGVKRLYGYVLK