Protein Info for b2663 in Escherichia coli BW25113

Name: gabP
Annotation: gamma-aminobutyrate transporter (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 466 transmembrane" amino acids 21 to 40 (20 residues), see Phobius details amino acids 46 to 66 (21 residues), see Phobius details amino acids 96 to 118 (23 residues), see Phobius details amino acids 124 to 144 (21 residues), see Phobius details amino acids 155 to 180 (26 residues), see Phobius details amino acids 200 to 222 (23 residues), see Phobius details amino acids 241 to 264 (24 residues), see Phobius details amino acids 287 to 308 (22 residues), see Phobius details amino acids 335 to 355 (21 residues), see Phobius details amino acids 361 to 381 (21 residues), see Phobius details amino acids 401 to 423 (23 residues), see Phobius details amino acids 429 to 449 (21 residues), see Phobius details TIGR01773: GABA permease" amino acids 1 to 452 (452 residues), 855.5 bits, see alignment E=4.2e-262 PF00324: AA_permease" amino acids 18 to 457 (440 residues), 464 bits, see alignment E=5.5e-143 PF13520: AA_permease_2" amino acids 19 to 430 (412 residues), 121 bits, see alignment E=6.6e-39

Best Hits

Swiss-Prot: 100% identical to GABP_ECOLI: GABA permease (gabP) from Escherichia coli (strain K12)

KEGG orthology group: K11735, GABA permease (inferred from 100% identity to eco:b2663)

MetaCyc: 100% identical to 4-aminobutanoate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-384; TRANS-RXN-57

Predicted SEED Role

"gamma-aminobutyrate (GABA) permease"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P25527 at UniProt or InterPro

Protein Sequence (466 amino acids)

>b2663 gamma-aminobutyrate transporter (NCBI) (Escherichia coli BW25113)
MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVM
IMRMLAEMAVATPDTGSFSTYADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSW
VPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIFLGAVAISGFYPY
AEVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNS
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSC
LNSALYTASRMLYSLSRRGDAPAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVF
KFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMWLYPWLTWLVIGFITFVLVV
MLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR