Protein Info for b2479 in Escherichia coli BW25113

Name: gcvR
Annotation: transcriptional regulation of gcv operon (VIMSS)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 190 PF13740: ACT_6" amino acids 7 to 82 (76 residues), 88.6 bits, see alignment E=3.2e-29

Best Hits

Swiss-Prot: 100% identical to GCVR_ECOLI: Glycine cleavage system transcriptional repressor (gcvR) from Escherichia coli (strain K12)

KEGG orthology group: K03567, glycine cleavage system transcriptional repressor (inferred from 100% identity to eco:b2479)

Predicted SEED Role

"Glycine cleavage system transcriptional antiactivator GcvR" in subsystem Glycine cleavage system or Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0A9I3 at UniProt or InterPro

Protein Sequence (190 amino acids)

>b2479 transcriptional regulation of gcv operon (VIMSS) (Escherichia coli BW25113)
MTLSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGEEFTFIMLLSGSWNA
ITLIESTLPLKGAELDLLIVMKRTTARPRPPMPASVWVQVDVADSPHLIERFTALFDAHH
MNIAELVSRTQPAENERAAQLHIQITAHSPASADAANIEQAFKALCTELNAQGSINVVNY
SQHDEQDGVK