Protein Info for b2386 in Escherichia coli BW25113

Name: ypdG
Annotation: predicted enzyme IIC component of PTS (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 415 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 46 to 68 (23 residues), see Phobius details amino acids 95 to 119 (25 residues), see Phobius details amino acids 159 to 178 (20 residues), see Phobius details amino acids 190 to 216 (27 residues), see Phobius details amino acids 239 to 258 (20 residues), see Phobius details amino acids 277 to 297 (21 residues), see Phobius details amino acids 317 to 335 (19 residues), see Phobius details amino acids 342 to 365 (24 residues), see Phobius details amino acids 380 to 402 (23 residues), see Phobius details PF02378: PTS_EIIC" amino acids 41 to 345 (305 residues), 52.2 bits, see alignment E=2.5e-18

Best Hits

Swiss-Prot: 100% identical to PTFC1_ECOLI: Fructose-like permease IIC component 1 (fryC) from Escherichia coli (strain K12)

KEGG orthology group: K11203, PTS system, fructose-specific IIC-like component (inferred from 100% identity to eco:b2386)

Predicted SEED Role

"PTS system, fructose-specific IIBC component (EC 2.7.1.69)" (EC 2.7.1.69)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P77579 at UniProt or InterPro

Protein Sequence (415 amino acids)

>b2386 predicted enzyme IIC component of PTS (NCBI) (Escherichia coli BW25113)
MAIKKRSATVVPGASGAAAAVKNPQASKTSFWGELPQHVMSGISRMVPTLIMGGVILAFS
QLIAYSWLKIPAEIGIMDALNSGKFSGFDLSLLKFAWLSQSFGGVLFGFAIPMFAAFVAN
SIGGKLAFPAGFIGGLMSTQPTQLLNFDPSTMQWATSSPVPSTFIGALIISIVAGYLVKW
MNQKIQLPDFLLAFKTTFLLPILSAIFVMLAMYYVITPFGGWINGGIRTVLTAAGEKGAL
MYAMGIAAATAIDLGGPINKAAGFVAFSFTTDHVLPVTARSIAIVIPPIGLGLATIIDRR
LTGKRLFNAQLYPQGKTAMFLAFMGISEGAIPFALESPITAIPSYMVGAIVGSTAAVWLG
AVQWFPESAIWAWPLVTNLGVYMAGIALGAVITALMVVFLRLMMFRKGKLLIDSL