Protein Info for b2381 in Escherichia coli BW25113

Name: ypdB
Annotation: predicted response regulator in two-component system withYpdA (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 244 PF00072: Response_reg" amino acids 3 to 112 (110 residues), 85.6 bits, see alignment E=2.8e-28 PF04397: LytTR" amino acids 146 to 242 (97 residues), 116.6 bits, see alignment E=4.9e-38

Best Hits

Swiss-Prot: 100% identical to YPDB_ECOLI: Transcriptional regulatory protein YpdB (ypdB) from Escherichia coli (strain K12)

KEGG orthology group: K02477, two-component system, LytT family, response regulator (inferred from 100% identity to eco:b2381)

Predicted SEED Role

"Hypothetical response regulatory protein ypdB"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0AE39 at UniProt or InterPro

Protein Sequence (244 amino acids)

>b2381 predicted response regulator in two-component system withYpdA (NCBI) (Escherichia coli BW25113)
MKVIIVEDEFLAQQELSWLIKEHSQMEIVGTFDDGLDVLKFLQHNRVDAIFLDINIPSLD
GVLLAQNISQFAHKPFIVFITAWKEHAVEAFELEAFDYILKPYQESRITGMLQKLEAAWQ
QQQTSSTPAATVTRENDTINLVKDERIIVTPINDIYYAEAHEKMTFVYTRRESYVMPMNI
TEFCSKLPPSHFFRCHRSFCVNLNKIREIEPWFNNTYILRLKDLDFEVPVSRSKVKEFRQ
LMHL