Protein Info for b2069 in Escherichia coli BW25113

Name: yegD
Annotation: putative heat shock protein (VIMSS)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 PF00012: HSP70" amino acids 3 to 228 (226 residues), 54.2 bits, see alignment E=8.1e-19 amino acids 330 to 422 (93 residues), 27.9 bits, see alignment E=7.4e-11 PF06723: MreB_Mbl" amino acids 136 to 229 (94 residues), 27 bits, see alignment E=2e-10

Best Hits

Swiss-Prot: 100% identical to YEGD_ECOLI: Uncharacterized chaperone protein YegD (yegD) from Escherichia coli (strain K12)

KEGG orthology group: K04046, hypothetical chaperone protein (inferred from 100% identity to eco:b2069)

Predicted SEED Role

"Putative heat shock protein YegD" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P36928 at UniProt or InterPro

Protein Sequence (450 amino acids)

>b2069 putative heat shock protein (VIMSS) (Escherichia coli BW25113)
MFIGFDYGTANCSVAVMRDGKPHLLKMENDSTLLPSMLCAPTREAVSEWLYRHHDVPADD
DETQALLRRAIRYNREEDIDVTAKSVQFGLSSLAQYIDDPEEVWFVKSPKSFLGASGLKP
QQVALFEDLVCAMMLHIRQQAQAQLPEAITQAVIGRPINFQGLGGDEANTQAQGILERAA
KRAGFRDVVFQYEPVAAGLDYEATLQEEKRVLVVDIGGGTTDCSLLLMGPQWRSRLDREA
SLLGHSGCRIGGNDLDIALAFKNLMPLLGMGGETEKGIALPILPWWNAVAINDVPAQSDF
YSSANGRLLNDLVRDAREPEKVALLQKVWRQRLSYRLVRSAEECKIALSSVAETRASLPF
ISNELATLISQRGLESALSQPLTRILEQVQLALDNAQEKPDVIYLTGGSARSPLIKKALA
EQLPGIPIAGGDDFGSVTAGLARWAEVVFR