Protein Info for b1967 in Escherichia coli BW25113

Name: hchA
Annotation: chaperone protein HchA (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.

Best Hits

Swiss-Prot: 100% identical to HCHA_ECODH: Protein/nucleic acid deglycase HchA (hchA) from Escherichia coli (strain K12 / DH10B)

KEGG orthology group: K05523, molecular chaperone HchA (Hsp31) (inferred from 100% identity to eco:b1967)

MetaCyc: 100% identical to protein/nucleic acid deglycase 1 (Escherichia coli K-12 substr. MG1655)
GLYOXIII-RXN [EC: 4.2.1.130]; RXN-17630 [EC: 4.2.1.130, 3.5.1.124]; 3.5.1.124 [EC: 4.2.1.130, 3.5.1.124]; 3.5.1.124 [EC: 4.2.1.130, 3.5.1.124]

Predicted SEED Role

"Chaperone protein hchA"

MetaCyc Pathways

• methylglyoxal degradation IX (1/1 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.124 or 4.2.1.130

Sequence Analysis Tools

See P31658 at UniProt or InterPro

Protein Sequence (283 amino acids)

>b1967 chaperone protein HchA (NCBI) (Escherichia coli BW25113)
MTVQTSKNPQVDIAEDNAFFPSEYSLSQYTSPVSDLDGVDYPKPYRGKHKILVIAADERY
LPTDNGKLFSTGNHPIETLLPLYHLHAAGFEFEVATISGLMTKFEYWAMPHKDEKVMPFF
EQHKSLFRNPKKLADVVASLNADSEYAAIFVPGGHGALIGLPESQDVAAALQWAIKNDRF
VISLCHGPAAFLALRHGDNPLNGYSICAFPDAADKQTPEIGYMPGHLTWYFGEELKKMGM
NIINDDITGRVHKDRKLLTGDSPFAANALGKLAAQEMLAAYAG