Protein Info for b1959 in Escherichia coli BW25113

Name: yedA
Annotation: predicted inner membrane protein (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 306 transmembrane" amino acids 7 to 27 (21 residues), see Phobius details amino acids 37 to 57 (21 residues), see Phobius details amino acids 68 to 88 (21 residues), see Phobius details amino acids 95 to 117 (23 residues), see Phobius details amino acids 124 to 143 (20 residues), see Phobius details amino acids 149 to 169 (21 residues), see Phobius details amino acids 178 to 199 (22 residues), see Phobius details amino acids 211 to 233 (23 residues), see Phobius details amino acids 244 to 262 (19 residues), see Phobius details amino acids 268 to 290 (23 residues), see Phobius details PF00892: EamA" amino acids 13 to 140 (128 residues), 84.4 bits, see alignment E=4.1e-28 amino acids 150 to 284 (135 residues), 68.4 bits, see alignment E=3.7e-23 TIGR00950: carboxylate/amino acid/amine transporter" amino acids 20 to 281 (262 residues), 238.3 bits, see alignment E=5e-75

Best Hits

Swiss-Prot: 100% identical to YEDA_ECOL6: Uncharacterized inner membrane transporter YedA (yedA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: None (inferred from 100% identity to eco:b1959)

Predicted SEED Role

"Permease of the drug/metabolite transporter (DMT) superfamily" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0AA70 at UniProt or InterPro

Protein Sequence (306 amino acids)

>b1959 predicted inner membrane protein (NCBI) (Escherichia coli BW25113)
MRFRQLLPLFGALFALYIIWGSTYFVIRIGVESWPPLMMAGVRFLAAGILLLAFLLLRGH
KLPPLRPLLNAALIGLLLLAVGNGMVTVAEHQNVPSGIAAVVVATVPLFTLCFSRLFGIK
TRKLEWVGIAIGLAGIIMLNSGGNLSGNPWGAILILIGSISWAFGSVYGSRITLPVGMMA
GAIEMLAAGVVLMIASMIAGEKLTALPSLSGFLAVGYLALFGSIIAINAYMYLIRNVSPA
LATSYAYVNPVVAVLLGTGLGGETLSKIEWLALGVIVFAVVLVTLGKYLFPAKPVVAPVI
QDASSE