Protein Info for b1830 in Escherichia coli BW25113

Name: prc
Annotation: carboxy-terminal protease for penicillin-binding protein 3 (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 682 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF17804: TSP_NTD" amino acids 49 to 232 (184 residues), 205.6 bits, see alignment E=1.7e-64 TIGR00225: C-terminal processing peptidase" amino acids 194 to 551 (358 residues), 434.5 bits, see alignment E=1.2e-134 PF00595: PDZ" amino acids 241 to 320 (80 residues), 45.3 bits, see alignment E=1.9e-15 PF03572: Peptidase_S41" amino acids 356 to 529 (174 residues), 167.4 bits, see alignment E=4.1e-53 PF11818: DUF3340" amino acids 536 to 667 (132 residues), 133.4 bits, see alignment E=1.5e-42

Best Hits

Swiss-Prot: 100% identical to PRC_ECOLI: Tail-specific protease (prc) from Escherichia coli (strain K12)

KEGG orthology group: K03797, carboxyl-terminal processing protease [EC: 3.4.21.102] (inferred from 100% identity to eck:EC55989_2007)

MetaCyc: 100% identical to tail-specific protease (Escherichia coli K-12 substr. MG1655)
C-terminal processing peptidase. [EC: 3.4.21.102]

Predicted SEED Role

"Tail-specific protease precursor (EC 3.4.21.102)" (EC 3.4.21.102)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.102

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P23865 at UniProt or InterPro

Protein Sequence (682 amino acids)

>b1830 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) (Escherichia coli BW25113)
MNMFFRLTALAGLLAIAGQTFAVEDITRADQIPVLKEETQHATVSERVTSRFTRSHYRQF
DLDQAFSAKIFDRYLNLLDYSHNVLLASDVEQFAKKKTELGDELRSGKLDVFYDLYNLAQ
KRRFERYQYALSVLEKPMDFTGNDTYNLDRSKAPWPKNEAELNALWDSKVKFDELSLKLT
GKTDKEIRETLTRRYKFAIRRLAQTNSEDVFSLAMTAFAREIDPHTNYLSPRNTEQFNTE
MSLSLEGIGAVLQMDDDYTVINSMVAGGPAAKSKAISVGDKIVGVGQTGKPMVDVIGWRL
DDVVALIKGPKGSKVRLEILPAGKGTKTRTVTLTRERIRLEDRAVKMSVKTVGKEKVGVL
DIPGFYVGLTDDVKVQLQKLEKQNVSSVIIDLRSNGGGALTEAVSLSGLFIPAGPIVQVR
DNNGKVREDSDTDGQVFYKGPLVVLVDRFSASASEIFAAAMQDYGRALVVGEPTFGKGTV
QQYRSLNRIYDQMLRPEWPALGSVQYTIQKFYRVNGGSTQRKGVTPDIIMPTGNEETETG
EKFEDNALPWDSIDAATYVKSGDLTAFEPELLKEHNARIAKDPEFQNIMKDIARFNAMKD
KRNIVSLNYAVREKENNEDDATRLARLNERFKREGKPELKKLDDLPKDYQEPDPYLDETV
NIALDLAKLEKARPAEQPAPVK