Protein Info for b1778 in Escherichia coli BW25113

Name: yeaA
Annotation: methionine sulfoxide reductase B (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00357: methionine-R-sulfoxide reductase
  • amino acids 4 to 136 (133 residues), 225.8 bits, E=7.4e-72
• PF01641: SelR
  • amino acids 9 to 127 (119 residues), 184 bits, E=4.4e-59

Best Hits

Swiss-Prot: 100% identical to MSRB_ECO27: Peptide methionine sulfoxide reductase MsrB (msrB) from Escherichia coli O127:H6 (strain E2348/69 / EPEC)

KEGG orthology group: K07305, peptide-methionine (R)-S-oxide reductase [EC: 1.8.4.12] (inferred from 100% identity to eco:b1778)

MetaCyc: 100% identical to methionine sulfoxide reductase B (Escherichia coli K-12 substr. MG1655)
L-methionine (R)-S-oxide reductase. [EC: 1.8.4.14]; Peptide-methionine (R)-S-oxide reductase. [EC: 1.8.4.14, 1.8.4.12]

Predicted SEED Role

"Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12)" (EC 1.8.4.12)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.4.12 or 1.8.4.14

Sequence Analysis Tools

See P0A746 at UniProt or InterPro

Protein Sequence (137 amino acids)

>b1778 methionine sulfoxide reductase B (NCBI) (Escherichia coli BW25113)
MANKPSAEELKKNLSEMQFYVTQNHGTEPPFTGRLLHNKRDGVYHCLICDAPLFHSQTKY
DSGCGWPSFYEPVSEESIRYIKDLSHGMQRIEIRCGNCDAHLGHVFPDGPQPTGERYCVN
SASLRFTDGENGEEING