Protein Info for b1634 in Escherichia coli BW25113

Name: tppB
Annotation: putative tripeptide transporter permease (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 transmembrane" amino acids 23 to 47 (25 residues), see Phobius details amino acids 60 to 80 (21 residues), see Phobius details amino acids 90 to 107 (18 residues), see Phobius details amino acids 113 to 131 (19 residues), see Phobius details amino acids 152 to 173 (22 residues), see Phobius details amino acids 179 to 200 (22 residues), see Phobius details amino acids 220 to 239 (20 residues), see Phobius details amino acids 245 to 264 (20 residues), see Phobius details amino acids 275 to 294 (20 residues), see Phobius details amino acids 323 to 341 (19 residues), see Phobius details amino acids 353 to 371 (19 residues), see Phobius details amino acids 386 to 408 (23 residues), see Phobius details amino acids 418 to 440 (23 residues), see Phobius details amino acids 457 to 477 (21 residues), see Phobius details TIGR00924: amino acid/peptide transporter (Peptide:H+ symporter)" amino acids 17 to 485 (469 residues), 461.6 bits, see alignment E=1.8e-142 PF07690: MFS_1" amino acids 35 to 371 (337 residues), 62.5 bits, see alignment E=3.5e-21 PF00854: PTR2" amino acids 89 to 447 (359 residues), 337.5 bits, see alignment E=1e-104

Best Hits

Swiss-Prot: 100% identical to DTPA_ECOLI: Dipeptide and tripeptide permease A (dtpA) from Escherichia coli (strain K12)

KEGG orthology group: K03305, proton-dependent oligopeptide transporter, POT family (inferred from 100% identity to eco:b1634)

MetaCyc: 100% identical to dipeptide/tripeptide:H+ symporter DtpA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-267; TRANS-RXN0-288

Predicted SEED Role

"Di/tripeptide permease DtpA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P77304 at UniProt or InterPro

Protein Sequence (500 amino acids)

>b1634 putative tripeptide transporter permease (NCBI) (Escherichia coli BW25113)
MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI
TLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMA
AIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWS
VAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTIIGVVALIAIATWLLH
NQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLN
FFAIRNVEHSILGLAVEPEQYQALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMC
SGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIM
GSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAP
KLHRMTQDDAADKAAKAAVA