Protein Info for b1620 in Escherichia coli BW25113

Name: malI
Annotation: DNA-binding transcriptional repressor (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 342 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF00356: LacI" amino acids 8 to 53 (46 residues), 67.2 bits, see alignment 1.7e-22 PF00532: Peripla_BP_1" amino acids 65 to 341 (277 residues), 360.4 bits, see alignment E=1.5e-111 PF13407: Peripla_BP_4" amino acids 67 to 268 (202 residues), 51.3 bits, see alignment E=2.5e-17 PF13377: Peripla_BP_3" amino acids 175 to 340 (166 residues), 47.3 bits, see alignment E=5.2e-16

Best Hits

Swiss-Prot: 100% identical to MALI_ECOLI: Maltose regulon regulatory protein MalI (malI) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to eco:b1620)

Predicted SEED Role

"Maltose regulon regulatory protein MalI (repressor for malXY)" in subsystem Maltose and Maltodextrin Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P18811 at UniProt or InterPro

Protein Sequence (342 amino acids)

>b1620 DNA-binding transcriptional repressor (NCBI) (Escherichia coli BW25113)
MATAKKITIHDVALAAGVSVSTVSLVLSGKGRISTATGERVNAAIEELGFVRNRQASALR
GGQSGVIGLIVRDLSAPFYAELTAGLTEALEAQGRMVFLLHGGKDGEQLAQRFSLLLNQG
VDGVVIAGAAGSSDDLRRMAEEKAIPVIFASRASYLDDVDTVRPDNMQAAQLLTEHLIRN
GHQRIAWLGGQSSSLTRAERVGGYCATLLKFGLPFHSDWVLECTSSQKQAAEAITALLRH
NPTISAVVCYNETIAMGAWFGLLKAGRQSGESGVDRYFEQQVSLAAFTDATPTTLDDIPV
TWASTPARELGITLADRMMQKITHEETHSRNLIIPARLIAAK