Protein Info for b1610 in Escherichia coli BW25113

Name: tus
Annotation: DNA replication terminus site-binding protein (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 309 PF05472: Ter" amino acids 9 to 306 (298 residues), 454.6 bits, see alignment E=6.7e-141 TIGR02648: DNA replication terminus site-binding protein" amino acids 10 to 308 (299 residues), 549.7 bits, see alignment E=8.2e-170

Best Hits

Swiss-Prot: 100% identical to TUS_ECOBW: DNA replication terminus site-binding protein (tus) from Escherichia coli (strain K12 / MC4100 / BW2952)

KEGG orthology group: K10748, DNA replication terminus site-binding protein (inferred from 100% identity to eco:b1610)

Predicted SEED Role

"DNA replication terminus site-binding protein" in subsystem DNA-replication

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P16525 at UniProt or InterPro

Protein Sequence (309 amino acids)

>b1610 DNA replication terminus site-binding protein (NCBI) (Escherichia coli BW25113)
MARYDLVDRLNTTFRQMEQELAIFAAHLEQHKLLVARVFSLPEVKKEDEHNPLNRIEVKQ
HLGNDAQSLALRHFRHLFIQQQSENRSSKAAVRLPGVLCYQVDNLSQAALVSHIQHINKL
KTTFEHIVTVESELPTAARFEWVHRHLPGLITLNAYRTLTVLHDPATLRFGWANKHIIKN
LHRDEVLAQLEKSLKSPRSVAPWTREEWQRKLEREYQDIAALPQNAKLKIKRPVKVQPIA
RVWYKGDQKQVQHACPTPLIALINRDNGAGVPDVGELLNYDADNVQHRYKPQAQPLRLII
PRLHLYVAD