Protein Info for b1444 in Escherichia coli BW25113

Name: ydcW
Annotation: medium chain aldehyde dehydrogenase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03374: 1-pyrroline dehydrogenase
  • amino acids 2 to 473 (472 residues), 1032.9 bits, E=0
• PF00171: Aldedh
  • amino acids 13 to 470 (458 residues), 560.8 bits, E=1e-172

Best Hits

Swiss-Prot: 100% identical to ABDH_ECOBW: Gamma-aminobutyraldehyde dehydrogenase (prr) from Escherichia coli (strain K12 / MC4100 / BW2952)

KEGG orthology group: K00137, aminobutyraldehyde dehydrogenase [EC: 1.2.1.19] (inferred from 100% identity to eco:b1444)

MetaCyc: 100% identical to gamma-aminobutyraldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.19]; 1.2.1.19 [EC: 1.2.1.19]

Predicted SEED Role

"4-aminobutyraldehyde dehydrogenase (EC 1.2.1.19)" in subsystem Polyamine Metabolism (EC 1.2.1.19)

MetaCyc Pathways

• superpathway of L-arginine and L-ornithine degradation (13/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (11/11 steps found)
• superpathway of ornithine degradation (8/8 steps found)
• L-lysine degradation I (7/7 steps found)
• L-lysine degradation X (5/6 steps found)
• putrescine degradation I (2/2 steps found)
• putrescine degradation IV (2/3 steps found)
• putrescine degradation V (1/2 steps found)
• superpathway of L-lysine degradation (14/43 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.19

Sequence Analysis Tools

See P77674 at UniProt or InterPro

Protein Sequence (474 amino acids)

>b1444 medium chain aldehyde dehydrogenase (NCBI) (Escherichia coli BW25113)
MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTP
KVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNG
LAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLT
ALKLAELAKDIFPAGVINILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSI
KRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKL
GAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGGEKRKGNGYYY
APTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHR
VSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH