Protein Info for b1324 in Escherichia coli BW25113

Name: tpx
Annotation: thiol peroxidase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08534: Redoxin
  • amino acids 20 to 163 (144 residues), 132.7 bits, E=9.4e-43
• PF00578: AhpC-TSA
  • amino acids 22 to 145 (124 residues), 59.5 bits, E=3.2e-20

Best Hits

Swiss-Prot: 100% identical to TPX_SHIFL: Thiol peroxidase (tpx) from Shigella flexneri

KEGG orthology group: K11065, thiol peroxidase, atypical 2-Cys peroxiredoxin [EC: 1.11.1.15] (inferred from 100% identity to eco:b1324)

MetaCyc: 100% identical to lipid hydroperoxide peroxidase (Escherichia coli K-12 substr. MG1655)
1.11.1.15-RXN [EC: 1.11.1.24]

Predicted SEED Role

"Thiol peroxidase, Tpx-type (EC 1.11.1.15)" in subsystem Thioredoxin-disulfide reductase (EC 1.11.1.15)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.15

Use Curated BLAST to search for 1.11.1.15 or 1.11.1.24

Sequence Analysis Tools

See P0A862 at UniProt or InterPro

Protein Sequence (168 amino acids)

>b1324 thiol peroxidase (NCBI) (Escherichia coli BW25113)
MSQTVHFQGNPVTVANSIPQAGSKAQTFTLVAKDLSDVTLGQFAGKRKVLNIFPSIDTGV
CAASVRKFNQLATEIDNTVVLCISADLPFAQSRFCGAEGLNNVITLSTFRNAEFLQAYGV
AIADGPLKGLAARAVVVIDENDNVIFSQLVDEITTEPDYEAALAVLKA