Protein Info for b1270 in Escherichia coli BW25113
Name: btuR
Annotation: cob(I)yrinic acid a,c-diamide adenosyltransferase (NCBI)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to BTUR_ECOL6: Corrinoid adenosyltransferase (btuR) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
KEGG orthology group: K00798, cob(I)alamin adenosyltransferase [EC: 2.5.1.17] (inferred from 100% identity to eco:b1270)MetaCyc: 89% identical to cob(I)yrinic acid a,c-diamide adenosyltransferase subunit (Salmonella enterica enterica serovar Typhimurium)
Cob(I)yrinic acid a,c-diamide adenosyltransferase. [EC: 2.5.1.17]; 2.5.1.17 [EC: 2.5.1.17]; 2.5.1.17 [EC: 2.5.1.17]
Predicted SEED Role
"Cob(I)alamin adenosyltransferase (EC 2.5.1.17)" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 2.5.1.17)
MetaCyc Pathways
- superpathway of adenosylcobalamin salvage from cobinamide I (8/8 steps found)
- adenosylcobalamin salvage from cobalamin (5/5 steps found)
- adenosylcobinamide-GDP salvage from cobinamide I (5/5 steps found)
- superpathway of adenosylcobalamin salvage from cobinamide II (7/9 steps found)
- adenosylcobinamide-GDP biosynthesis from cobyrinate a,c-diamide (4/6 steps found)
- adenosylcobinamide-GDP salvage from cobinamide II (4/6 steps found)
- cobalamin salvage (eukaryotic) (4/8 steps found)
- adenosylcobalamin biosynthesis II (aerobic) (17/33 steps found)
- adenosylcobalamin biosynthesis I (anaerobic) (16/36 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.5.1.17
Use Curated BLAST to search for 2.5.1.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See P0A9H5 at UniProt or InterPro
Protein Sequence (196 amino acids)
>b1270 cob(I)yrinic acid a,c-diamide adenosyltransferase (NCBI) (Escherichia coli BW25113) MSDERYQQRQQRVKEKVDARVAQAQDERGIIIVFTGNGKGKTTAAFGTATRAVGHGKKVG VVQFIKGTWPNGERNLLEPHGVEFQVMATGFTWDTQNRESDTAACREVWQHAKRMLADSS LDMVLLDELTYMVAYDYLPLEEVVQALNERPHQQTVIITGRGCHRDILELADTVSELRPV KHAFDAGVKAQIGIDY