Protein Info for b1096 in Escherichia coli BW25113

Name: pabC
Annotation: 4-amino-4-deoxychorismate lyase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03461: aminodeoxychorismate lyase
  • amino acids 3 to 262 (260 residues), 379.1 bits, E=4.7e-118
• PF01063: Aminotran_4
  • amino acids 24 to 246 (223 residues), 174.9 bits, E=1.1e-55

Best Hits

Swiss-Prot: 100% identical to PABC_ECOLI: Aminodeoxychorismate lyase (pabC) from Escherichia coli (strain K12)

KEGG orthology group: K02619, 4-amino-4-deoxychorismate lyase [EC: 4.1.3.38] (inferred from 100% identity to eco:b1096)

MetaCyc: 100% identical to aminodeoxychorismate lyase (Escherichia coli K-12 substr. MG1655)
Aminodeoxychorismate lyase. [EC: 4.1.3.38]

Predicted SEED Role

"Aminodeoxychorismate lyase (EC 4.1.3.38)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Folate Biosynthesis (EC 4.1.3.38)

MetaCyc Pathways

• superpathway of chorismate metabolism (54/59 steps found)
• superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
• superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
• 4-aminobenzoate biosynthesis I (2/2 steps found)
• 4-aminobenzoate biosynthesis II (1/2 steps found)
• superpathway of candicidin biosynthesis (4/11 steps found)

KEGG Metabolic Maps

• Biosynthesis of phenylpropanoids
• Folate biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.3.38

Sequence Analysis Tools

See P28305 at UniProt or InterPro

Protein Sequence (269 amino acids)

>b1096 4-amino-4-deoxychorismate lyase (NCBI) (Escherichia coli BW25113)
MFLINGHKQESLAVSDRATQFGDGCFTTARVIDGKVSLLSAHIQRLQDACQRLMISCDFW
PQLEQEMKTLAAEQQNGVLKVVISRGSGGRGYSTLNSGPATRILSVTAYPAHYDRLRNEG
ITLALSPVRLGRNPHLAGIKHLNRLEQVLIRSHLEQTNADEALVLDSEGWVTECCAANLF
WRKGNVVYTPRLDQAGVNGIMRQFCIRLLAQSSYQLVEVQASLEESLQADEMVICNALMP
VMPVCACGDVSFSSATLYEYLAPLCERPN