Protein Info for b1068 in Escherichia coli BW25113

Name: mviM
Annotation: predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 307 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF01408: GFO_IDH_MocA" amino acids 4 to 121 (118 residues), 101.8 bits, see alignment E=4.3e-33 PF21378: YceM-like_C" amino acids 127 to 245 (119 residues), 168.6 bits, see alignment E=6.3e-54

Best Hits

Swiss-Prot: 100% identical to YCEM_ECOLI: Putative oxidoreductase YceM (yceM) from Escherichia coli (strain K12)

KEGG orthology group: K03810, virulence factor (inferred from 100% identity to eco:b1068)

Predicted SEED Role

"Virulence factor MviM" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P75931 at UniProt or InterPro

Protein Sequence (307 amino acids)

>b1068 predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain (NCBI) (Escherichia coli BW25113)
MKKLRIGVVGLGGIAQKAWLPVLAAASDWTLQGAWSPTRAKALPICESWRIPYADSLSSL
AASCDAVFVHSSTASHFDVVSTLLNAGVHVCVDKPLAENLRDAERLVELAARKKLTLMVG
FNRRFAPLYGELKTQLATAASLRMDKHRSNSVGPHDLYFTLLDDYLHVVDTALWLSGGKA
SLDGGTLLTNDAGEMLFAEHHFSAGPLQITTCMHRRAGSQRETVQAVTDGALIDITDMRE
WREERGQGVVHKPIPGWQSTLEQRGFVGCARHFIECVQNQTVPQTAGEQAVLAQRIVDKI
WRDAMSE