Protein Info for b0733 in Escherichia coli BW25113

Name: cydA
Annotation: cytochrome d terminal oxidase, polypeptide subunit I (VIMSS)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 522 transmembrane" amino acids 18 to 42 (25 residues), see Phobius details amino acids 54 to 73 (20 residues), see Phobius details amino acids 93 to 116 (24 residues), see Phobius details amino acids 128 to 150 (23 residues), see Phobius details amino acids 185 to 208 (24 residues), see Phobius details amino acids 220 to 238 (19 residues), see Phobius details amino acids 387 to 409 (23 residues), see Phobius details amino acids 421 to 443 (23 residues), see Phobius details amino acids 471 to 494 (24 residues), see Phobius details PF01654: Cyt_bd_oxida_I" amino acids 7 to 501 (495 residues), 569.8 bits, see alignment E=1.5e-175

Best Hits

Swiss-Prot: 100% identical to CYDA_ECOL6: Cytochrome bd-I ubiquinol oxidase subunit 1 (cydA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K00425, cytochrome bd-I oxidase subunit I [EC: 1.10.3.-] (inferred from 100% identity to eco:b0733)

MetaCyc: 100% identical to cytochrome bd-I subunit 1 (Escherichia coli K-12 substr. MG1655)
RXN0-5266 [EC: 7.1.1.7]; 1.11.1.- [EC: 7.1.1.7]; 1.11.1.- [EC: 7.1.1.7]

Predicted SEED Role

"Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-)" in subsystem Terminal cytochrome d ubiquinol oxidases or Terminal cytochrome oxidases (EC 1.10.3.-)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.10.3.-

Use Curated BLAST to search for 1.10.3.- or 7.1.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0ABJ9 at UniProt or InterPro

Protein Sequence (522 amino acids)

>b0733 cytochrome d terminal oxidase, polypeptide subunit I (VIMSS) (Escherichia coli BW25113)
MLDIVELSRLQFALTAMYHFLFVPLTLGMAFLLAIMETVYVLSGKQIYKDMTKFWGKLFG
INFALGVATGLTMEFQFGTNWSYYSHYVGDIFGAPLAIEGLMAFFLESTFVGLFFFGWDR
LGKVQHMCVTWLVALGSNLSALWILVANGWMQNPIASDFNFETMRMEMVSFSELVLNPVA
QVKFVHTVASGYVTGAMFILGISAWYMLKGRDFAFAKRSFAIAASFGMAAVLSVIVLGDE
SGYEMGDVQKTKLAAIEAEWETQPAPAAFTLFGIPDQEEETNKFAIQIPYALGIIATRSV
DTPVIGLKELMVQHEERIRNGMKAYSLLEQLRSGSTDQAVRDQFNSMKKDLGYGLLLKRY
TPNVADATEAQIQQATKDSIPRVAPLYFAFRIMVACGFLLLAIIALSFWSVIRNRIGEKK
WLLRAALYGIPLPWIAVEAGWFVAEYGRQPWAIGEVLPTAVANSSLTAGDLIFSMVLICG
LYTLFLVAELFLMFKFARLGPSSLKTGRYHFEQSSTTTQPAR