Protein Info for b0437 in Escherichia coli BW25113

Name: clpP
Annotation: ATP-dependent Clp protease proteolytic subunit (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 207 TIGR00493: ATP-dependent Clp endopeptidase, proteolytic subunit ClpP" amino acids 14 to 205 (192 residues), 369.6 bits, see alignment E=1.6e-115 PF00574: CLP_protease" amino acids 26 to 205 (180 residues), 298.1 bits, see alignment E=1.3e-93

Best Hits

Swiss-Prot: 100% identical to CLPP_ECOLI: ATP-dependent Clp protease proteolytic subunit (clpP) from Escherichia coli (strain K12)

KEGG orthology group: K01358, ATP-dependent Clp protease, protease subunit [EC: 3.4.21.92] (inferred from 100% identity to eco:b0437)

MetaCyc: 100% identical to ATP-dependent Clp protease proteolytic subunit (Escherichia coli K-12 substr. MG1655)
Endopeptidase Clp. [EC: 3.4.21.92]

Predicted SEED Role

"ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent or cAMP signaling in bacteria (EC 3.4.21.92)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.92

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0A6G7 at UniProt or InterPro

Protein Sequence (207 amino acids)

>b0437 ATP-dependent Clp protease proteolytic subunit (NCBI) (Escherichia coli BW25113)
MSYSGERDNFAPHMALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQ
MLFLEAENPEKDIYLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAG
AKGKRFCLPNSRVMIHQPLGGYQGQATDIEIHAREILKVKGRMNELMALHTGQSLEQIER
DTERDRFLSAPEAVEYGLVDSILTHRN