Protein Info for b0069 in Escherichia coli BW25113

Name: sgrR
Annotation: DNA-binding transcriptional regulator (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 551 PF12793: SgrR_N" amino acids 5 to 118 (114 residues), 143.9 bits, see alignment E=2.5e-46 PF00496: SBP_bac_5" amino acids 165 to 306 (142 residues), 69.8 bits, see alignment E=2.5e-23

Best Hits

Swiss-Prot: 100% identical to SGRR_ECOLI: HTH-type transcriptional regulator SgrR (sgrR) from Escherichia coli (strain K12)

KEGG orthology group: K11925, SgrR family transcriptional regulator (inferred from 100% identity to eco:b0069)

Predicted SEED Role

"SgrR, sugar-phosphate stress, transcriptional activator of SgrS small RNA" in subsystem Sugar-phosphate stress regulation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P33595 at UniProt or InterPro

Protein Sequence (551 amino acids)

>b0069 DNA-binding transcriptional regulator (NCBI) (Escherichia coli BW25113)
MPSARLQQQFIRLWQCCEGKSQDTTLNELAALLSCSRRHMRTLLNTMQDRGWLTWEAEVG
RGKRSRLTFLYTGLALQQQRAEDLLEQDRIDQLVQLVGDKATVRQMLVSHLGRSFRQGRH
ILRVLYYRPLRNLLPGSALRRSETHIARQIFSSLTRINEENGELEADIAHHWQQISPLHW
RFFLRPGVHFHHGRELEMDDVIASLKRINTLPLYSHIADIVSPTPWTLDIHLTQPDRWLP
LLLGQVPAMILPREWETLSNFASHPIGTGPYAVIRNSTNQLKIQAFDDFFGYRALIDEVN
VWVLPEIADEPAGGLMLKGPQGEEKEIESRLEEGCYYLLFDSRTHRGANQQVRDWVSYVL
SPTNLVYFAEEQYQQLWFPAYGLLPRWHHARTIKSEKPAGLESLTLTFYQDHSEHRVIAG
IMQQILASHQVTLKIKEIDYDQWHTGEIESDIWLNSANFTLPLDFSVFAHLCEVPLLQHC
IPIDWQADAARWRNGEMNLANWCQQLVASKAMVPLLHHWLIIQGQRSMRGLRMNTLGWFD
FKSAWFAPPDP