Protein Info for b0053 in Escherichia coli BW25113

Name: surA
Annotation: peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 428 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF09312: SurA_N" amino acids 25 to 142 (118 residues), 157 bits, see alignment E=5.7e-50 PF13624: SurA_N_3" amino acids 27 to 141 (115 residues), 47.4 bits, see alignment E=5e-16 PF13616: Rotamase_3" amino acids 165 to 272 (108 residues), 66.9 bits, see alignment E=6e-22 amino acids 281 to 383 (103 residues), 94 bits, see alignment E=2.4e-30 PF00639: Rotamase" amino acids 178 to 272 (95 residues), 77.5 bits, see alignment E=3.2e-25 amino acids 289 to 380 (92 residues), 89.3 bits, see alignment E=6.6e-29 PF13145: Rotamase_2" amino acids 193 to 275 (83 residues), 31 bits, see alignment E=9.9e-11 amino acids 303 to 383 (81 residues), 32.6 bits, see alignment E=3e-11

Best Hits

Swiss-Prot: 100% identical to SURA_SHIBS: Chaperone SurA (surA) from Shigella boydii serotype 4 (strain Sb227)

KEGG orthology group: K03771, peptidyl-prolyl cis-trans isomerase SurA [EC: 5.2.1.8] (inferred from 100% identity to eco:b0053)

MetaCyc: 100% identical to chaperone SurA (Escherichia coli K-12 substr. MG1655)
Peptidylprolyl isomerase. [EC: 5.2.1.8]

Predicted SEED Role

"Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P0ABZ6 at UniProt or InterPro

Protein Sequence (428 amino acids)

>b0053 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) (Escherichia coli BW25113)
MKNWKTLLLGIAMIANTSFAAPQVVDKVAAVVNNGVVLESDVDGLMQSVKLNAAQARQQL
PDDATLRHQIMERLIMDQIILQMGQKMGVKISDEQLDQAIANIAKQNNMTLDQMRSRLAY
DGLNYNTYRNQIRKEMIISEVRNNEVRRRITILPQEVESLAQQVGNQNDASTELNLSHIL
IPLPENPTSDQVNEAESQARAIVDQARNGADFGKLAIAHSADQQALNGGQMGWGRIQELP
GIFAQALSTAKKGDIVGPIRSGVGFHILKVNDLRGESKNISVTEVHARHILLKPSPIMTD
EQARVKLEQIAADIKSGKTTFAAAAKEFSQDPGSANQGGDLGWATPDIFDPAFRDALTRL
NKGQMSAPVHSSFGWHLIELLDTRNVDKTDAAQKDRAYRMLMNRKFSEEAASWMQEQRAS
AYVKILSN