Negative cofitness for PP_4403 from Pseudomonas putida KT2440

Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex
SEED: Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168)
KEGG: 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase)

Computing cofitness values with 989 experiments...

Genes with the strongest negative cofitness:

Rank	Hit	Name	Description	Cofit
1	PP_4776		AsnC family transcriptional regulator	-0.36
2	PP_2389		conserved protein of unknown function	-0.31
3	PP_3286		DNA-binding transcriptional repressor PaaX(phenylacetyl-CoA)	-0.24
4	PP_4011		isocitrate dehydrogenase, NADP(+)-specific	-0.22
5	PP_2430		Transcriptional regulator, AraC family	-0.22
6	PP_4006		Putative arginyl-tRNA--protein transferase	-0.22
7	PP_3415		Transcriptional regulator, LacI family	-0.22
8	PP_4697		poly(A) polymerase	-0.22
9	PP_1059		Uncharacterized amino acid permease YtnA	-0.22
10	PP_2390		Transcriptional regulator, LysR family	-0.21
11	PP_4756		gamma-aminobutyrate permease	-0.21
12	PP_2457		DNA-binding transcriptional repressor	-0.21
13	PP_2388		Transporter, LysE family	-0.19
14	PP_1074		DNA-binding transcriptional repressor - GlpR-glycerol-3-phosphate	-0.18
15	PP_2082		phosphoenolpyruvate synthetase	-0.18
16	PP_4484		histidine / lysine / arginine / ornithine ABC transporter - permease subunit	-0.18
17	PP_0339		Pyruvate dehydrogenase E1 component	-0.18
18	PP_2387		conserved protein of unknown function	-0.18
19	PP_2458		ribokinase	-0.18
20	PP_0987		L-serine dehydratase	-0.16

Or look for positive cofitness