Negative cofitness for PP_0516 from Pseudomonas putida KT2440

3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
SEED: 3,4-dihydroxy-2-butanone 4-phosphate synthase (EC 4.1.99.12) / GTP cyclohydrolase II (EC 3.5.4.25)
KEGG: 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II

Computing cofitness values with 989 experiments...

Genes with the strongest negative cofitness:

Rank	Hit	Name	Description	Cofit
1	PP_4483		histidine lysine / arginine / ornithine ABC transporter - ATP binding subunit	-0.23
2	PP_3246		Beta-carotene hydroxylase	-0.22
3	PP_4484		histidine / lysine / arginine / ornithine ABC transporter - permease subunit	-0.21
4	PP_3889		putative Phage integrase	-0.19
5	PP_1241		conserved protein of unknown function	-0.18
6	PP_4485		histidine / lysine / arginine / ornithine ABC transporter - permease subunit	-0.18
7	PP_4510		conserved protein of unknown function	-0.18
8	PP_0582		Thiolase family protein	-0.16
9	PP_4946		sodium/L-proline transporter	-0.16
10	PP_0882		dipeptide ABC transporter - periplasmic binding protein	-0.16
11	PP_5023		Amino acid ABC transporter, permease protein	-0.15
12	PP_5218		DedA family protein	-0.15
13	PP_3644		putative Monooxygenase subunit	-0.15
14	PP_2428		Probable sugar efflux transporter	-0.14
15	PP_3722		Alanine racemase	-0.14
16	PP_0573		conserved protein of unknown function	-0.14
17	PP_3727		Amino-acid permease RocE	-0.14
18	PP_2574		Transcriptional regulator, LysR family	-0.14
19	PP_3745		glycolate oxidase, putative FAD-linked subunit	-0.14
20	PP_4945		23S rRNA m(6)A2030 methyltransferase	-0.14

Or look for positive cofitness