Negative cofitness for MIT1002_02635 from Alteromonas macleodii MIT1002

Histidine biosynthesis bifunctional protein HisB
SEED: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
KEGG: imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase

Computing cofitness values with 52 experiments...

Genes with the strongest negative cofitness:

Rank	Hit	Name	Description	Cofit
1	MIT1002_02953		hypothetical protein	-0.58
2	MIT1002_00379		hypothetical protein	-0.48
3	MIT1002_01782		Endonuclease/Exonuclease/phosphatase family protein	-0.46
4	MIT1002_00125		hypothetical protein	-0.45
5	MIT1002_01302		Thermostable monoacylglycerol lipase	-0.45
6	MIT1002_02588		Long-chain-fatty-acid--CoA ligase	-0.43
7	MIT1002_03554		Flagellin N-methylase	-0.42
8	MIT1002_02749		bile acid transporter	-0.39
9	MIT1002_01805		NADH oxidase	-0.39
10	MIT1002_01088		Flagellum-specific ATP synthase	-0.39
11	MIT1002_03911		Flavin-dependent tryptophan halogenase RebH	-0.39
12	MIT1002_00577		Xaa-Pro dipeptidase	-0.39
13	MIT1002_00122		UvsW helicase	-0.39
14	MIT1002_02433		2-dehydro-3-deoxy-phosphogluconate aldolase	-0.39
15	MIT1002_03877		Peptidyl-tRNA hydrolase YaeJ	-0.39
16	MIT1002_00635		Leucine-responsive regulatory protein	-0.38
17	MIT1002_03697		putative membrane protein YjcC	-0.38
18	MIT1002_00657		hypothetical protein	-0.38
19	MIT1002_02914		hypothetical protein	-0.37
20	MIT1002_01238		fec operon regulator FecR	-0.37

Or look for positive cofitness