Negative cofitness for GFF4223 from Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
SEED: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
KEGG: 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit

Computing cofitness values with 79 experiments...

Genes with the strongest negative cofitness:

Rank	Hit	Name	Description	Cofit
1	GFF1975		Putative ion-channel protein	-0.68
2	GFF3277		Homoprotocatechuate degradative operon repressor	-0.58
3	GFF864		NADPH:quinone oxidoreductase 2	-0.54
4	GFF4863		'LSU rRNA 2'-O-methyl-C2498 methyltransferase RlmM' transl_table=11	-0.54
5	GFF3761		Lipoprotein spr precursor	-0.54
6	GFF1522		Galactitol utilization operon repressor	-0.54
7	GFF2324		Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)	-0.53
8	GFF866		'2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16)' transl_table=11	-0.53
9	GFF4502		Isochorismatase (EC 3.3.2.1) of siderophore biosynthesis	-0.52
10	GFF423		Aldehyde dehydrogenase B (EC 1.2.1.22)	-0.52
11	GFF4183		COG1496: Uncharacterized conserved protein	-0.51
12	GFF3954		Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)	-0.50
13	GFF2771		FIG002708: Protein SirB1	-0.50
14	GFF4028		Flagellar hook-associated protein FliD	-0.49
15	GFF4478		PTS system, mannose-specific IID component (EC 2.7.1.69)	-0.49
16	GFF226		Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives)	-0.49
17	GFF618		33 kDa chaperonin (Heat shock protein 33) (HSP33)	-0.49
18	GFF1268		Putative antirestriction protein	-0.49
19	GFF4384		Putative inner membrane protein	-0.48
20	GFF908		FIG00628496: hypothetical protein	-0.48

Or look for positive cofitness