Negative cofitness for Echvi_4117 from Echinicola vietnamensis KMM 6221, DSM 17526

heavy metal efflux pump (cobalt-zinc-cadmium)
SEED: Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA

Computing cofitness values with 221 experiments...

Genes with the strongest negative cofitness:

Rank	Hit	Name	Description	Cofit
1	Echvi_2813		Amino acid permeases	-0.28
2	Echvi_2475		Predicted amino acid aldolase or racemase	-0.25
3	Echvi_1243		glutamate synthases, NADH/NADPH, small subunit	-0.25
4	Echvi_4210		RND family efflux transporter, MFP subunit	-0.25
5	Echvi_2621		Predicted metal-dependent hydrolase of the TIM-barrel fold	-0.25
6	Echvi_1295		diaminopimelate decarboxylase (EC 4.1.1.20) (from data)	-0.24
7	Echvi_0123		prephenate and/or arogenate dehydratase (EC 4.2.1.51) (from data)	-0.24
8	Echvi_2001		homoserine kinase (EC 2.7.1.39) (from data)	-0.24
9	Echvi_4209		Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-0.24
10	Echvi_3285		homoserine O-acetyltransferase	-0.24
11	Echvi_3850		acetylglutamate kinase	-0.24
12	Echvi_2002		threonine synthase	-0.23
13	Echvi_1244		Glutamate synthase domain 2	-0.23
14	Echvi_3846		argininosuccinate synthase	-0.23
15	Echvi_3852		arginosuccinate lyase (EC 4.3.2.1) (from data)	-0.23
16	Echvi_2777		fused D-3-phosphoglycerate dehydrogenase / phosphoserine phosphatase (EC 1.1.1.95; EC 3.1.3.3) (from data)	-0.23
17	Echvi_2283		Cystathionine beta-lyases/cystathionine gamma-synthases	-0.23
18	Echvi_3108		Predicted transcriptional regulator	-0.23
19	Echvi_3833		2-isopropylmalate synthase (EC 2.3.3.13) (from data)	-0.23
20	Echvi_2000		aspartate kinase / homoserine dehydrogenase (EC 2.7.2.4; EC 1.1.1.3) (from data)	-0.23

Or look for positive cofitness