Negative cofitness for ECD_03871 from Escherichia coli BL21

phosphomethylpyrimidine synthase
SEED: Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17)
KEGG: thiamine biosynthesis protein ThiC

Computing cofitness values with 101 experiments...

Genes with the strongest negative cofitness:

Rank	Hit	Name	Description	Cofit
1	ECD_02627		mRNA interferase toxin, antitoxin is MazE	-0.47
2	ECD_02592		activator of AmiC murein hydrolase activity, lipoprotein	-0.46
3	ECD_02579		hydrogenase maturation protein	-0.44
4	ECD_02659		glycine cleavage system transcriptional activator; autorepressor	-0.44
5	ECD_00235		DNA-binding transcriptional regulator	-0.43
6	ECD_03703		homoserine, homoserine lactone and S-methyl-methionine efflux pump	-0.43
7	ECD_04222		4-hydroxyphenylacetate 3-monooxygenase	-0.43
8	ECD_00812		putative drug efflux MFS transporter, inner membrane protein	-0.41
9	ECD_00150		iron(3+)-hydroxamate import ABC transporter ATPase	-0.41
10	ECD_02346		aldehyde oxidoreductase, ethanolamine utilization protein	-0.40
11	ECD_01071		flagellar hook assembly protein	-0.40
12	ECD_03922		phage shock protein G	-0.40
13	ECD_01020		inactive ferrous ion transporter EfeUOB	-0.39
14	ECD_02569		hydrogenase 3 and formate hydrogenase complex, HycG subunit	-0.39
15	ECD_03202		potassium-efflux system ancillary protein for KefB, glutathione-regulated	-0.38
16	ECD_03898		extracellular polysaccharide production threonine-rich protein	-0.38
17	ECD_00028		uncharacterized protein	-0.37
18	ECD_03772		D-tyr-tRNA(Tyr) deacylase	-0.37
19	ECD_03916		oxidative stress resistance protein; putative MATE family efflux pump; UV and mitomycin C inducible protein	-0.37
20	ECD_02561		NADH:flavorubredoxin oxidoreductase	-0.37

Or look for positive cofitness