Negative cofitness for DZA65_RS03450 from Dickeya dianthicola ME23

HD domain-containing protein
SEED: HMP-PP hydrolase (pyridoxal phosphatase) Cof, detected in genetic screen for thiamin metabolic genes (PMID:15292217)
KEGG: putative hydrolases of HD superfamily

Computing cofitness values with 77 experiments...

Genes with the strongest negative cofitness:

Rank	Hit	Name	Description	Cofit
1	DZA65_RS18275		HAMP domain-containing protein	-0.51
2	DZA65_RS22840		hypothetical protein	-0.47
3	DZA65_RS12490		two-component system response regulator NarL	-0.47
4	DZA65_RS17415		tRNA-Arg	-0.46
5	DZA65_RS00905		ThiF family adenylyltransferase	-0.45
6	DZA65_RS21925		2-hydroxycarboxylate transporter family protein	-0.44
7	DZA65_RS19405		FKBP-type peptidyl-prolyl cis-trans isomerase	-0.43
8	DZA65_RS22220		oxygen-independent coproporphyrinogen III oxidase	-0.43
9	DZA65_RS08170		formate dehydrogenase-N subunit alpha	-0.43
10	DZA65_RS12770		acid resistance repetitive basic protein Asr	-0.43
11	DZA65_RS10255		helix-turn-helix transcriptional regulator	-0.42
12	DZA65_RS21140		amidohydrolase	-0.41
13	DZA65_RS08180		formate dehydrogenase-N subunit gamma	-0.41
14	DZA65_RS09580		deoxyribonuclease IV	-0.40
15	DZA65_RS02770		SIR2 family protein	-0.40
16	DZA65_RS05700		DUF1987 domain-containing protein	-0.40
17	DZA65_RS12465		nitrate reductase subunit alpha	-0.40
18	DZA65_RS07800		DUF4160 domain-containing protein	-0.39
19	DZA65_RS12460		nitrate reductase subunit beta	-0.39
20	DZA65_RS21080		DNA helicase II	-0.39

Or look for positive cofitness