Negative cofitness for b0522 from Escherichia coli BW25113

purK: phosphoribosylaminoimidazole carboxylase (NCBI)
SEED: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)
KEGG: 5-(carboxyamino)imidazole ribonucleotide synthase

Computing cofitness values with 1179 experiments...

Genes with the strongest negative cofitness:

Rank	Hit	Name	Description	Cofit
1	b3929	rraA	ribonuclease activity regulator protein RraA (NCBI)	-0.56
2	b1085	b1085	orf, hypothetical protein (VIMSS)	-0.50
3	b0059	hepA	ATP-dependent helicase HepA (NCBI)	-0.47
4	b2829	ptsP	fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI)	-0.45
5	b1916	sdiA	DNA-binding transcriptional activator (NCBI)	-0.45
6	b2474	ypfI	predicted hydrolase (NCBI)	-0.45
7	b3616	tdh	L-threonine 3-dehydrogenase (NCBI)	-0.44
8	b0382	yaiB	hypothetical protein (NCBI)	-0.43
9	b0240	crl	DNA-binding transcriptional regulator (NCBI)	-0.43
10	b3753	rbsR	DNA-binding transcriptional repressor of ribose metabolism (NCBI)	-0.41
11	b1824	yobF	hypothetical protein (NCBI)	-0.40
12	b1634	tppB	putative tripeptide transporter permease (NCBI)	-0.40
13	b2521	sseA	putative thiosulfate sulfurtransferase (VIMSS)	-0.40
14	b3523	yhjE	predicted transporter (NCBI)	-0.39
15	b2903	gcvP	glycine dehydrogenase (NCBI)	-0.38
16	b2341	yfcX	fused enoyl-CoA hydratase and epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase (NCBI)	-0.38
17	b2904	gcvH	glycine cleavage system protein H (NCBI)	-0.38
18	b4071	nrfB	formate-dependent nitrite reductase; a penta-haeme cytochrome c (VIMSS)	-0.37
19	b0955	ycbZ	predicted peptidase (NCBI)	-0.37
20	b2808	gcvA	DNA-binding transcriptional dual regulator (NCBI)	-0.37

Or look for positive cofitness