Top cofit genes for ECD_04216 from Escherichia coli BL21

endonuclease R Type I restriction enzyme
SEED: Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)
KEGG: type I restriction enzyme, R subunit

Rank	Hit	Name	Description	Conserved?	Cofitness
1	ECD_02993		D-galactarate dehydrogenase	no	0.74
2	ECD_02552		glucitol/sorbitol-specific enzyme IIC component of PTS	no	0.72
3	ECD_02753		oxidative stress defense protein	no	0.71
4	ECD_00678		putative outer membrane protein	no	0.69
5	ECD_02787		periplasmic L-asparaginase 2	0.19	0.67
6	ECD_02841		bifunctional prepilin leader peptidase/ methylase	no	0.67
7	ECD_02773		D-galactose transporter	no	0.66
8	ECD_00410		maltose O-acetyltransferase	no	0.66
9	ECD_04008		C4-dicarboxylate antiporter	no	0.66
10	ECD_02870		hydrogenase 2, large subunit	no	0.66
11	ECD_02860		putative ATP-binding protein	no	0.65
12	ECD_02888		Radical SAM superfamily protein	no	0.65
13	ECD_03280		glycogen phosphorylase	no	0.65
14	ECD_02838		putative type II secretion protein GspD	no	0.65
15	ECD_02842		putative secreted and surface-associated lipoprotein mucinase	no	0.65
16	ECD_02849		glycolate-inducible glc operon transcriptional repressor; autorepressor	no	0.64
17	ECD_02731		hemolysin III family HylIII inner membrane protein	no	0.64
18	ECD_02760		MtlR family putative transcriptional repressor	no	0.64
19	ECD_02949		alpha-glucosidase	no	0.64
20	ECD_02831		putative type II secretion protein GspK	no	0.64

Or look for negative cofitness