Top cofit genes for ECD_03871 from Escherichia coli BL21

phosphomethylpyrimidine synthase
SEED: Hydroxymethylpyrimidine phosphate synthase ThiC (EC 4.1.99.17)
KEGG: thiamine biosynthesis protein ThiC

Rank	Hit	Name	Description	Conserved?	Cofitness
1	ECD_02449		phosphoribosylformyl-glycineamide synthetase	0.90	0.66
2	ECD_03882		phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase	0.89	0.65
3	ECD_03883		IMP cyclohydrolase and phosphoribosylaminoimidazolecarboxamide formyltransferase	0.90	0.65
4	ECD_00473		N5-carboxyaminoimidazole ribonucleotide mutase	0.87	0.65
5	ECD_03499		orotate phosphoribosyltransferase	0.92	0.63
6	ECD_02237		amidophosphoribosyltransferase	0.89	0.62
7	ECD_01237		fused glutamine amidotransferase (component II) of anthranilate synthase/anthranilate phosphoribosyl transferase	0.86	0.62
8	ECD_00053		diadenosine tetraphosphatase	0.47	0.61
9	ECD_01925		imidazole glycerol phosphate synthase, glutamine amidotransferase subunit	0.83	0.61
10	ECD_02391		phosphoribosylaminoimidazole synthetase	0.93	0.61
11	ECD_03866		tyrosine lyase, involved in thiamine-thiazole moiety synthesis	0.98	0.61
12	ECD_00911		3-phosphoserine/phosphohydroxythreonine aminotransferase	0.87	0.60
13	ECD_00037		carbamoyl-phosphate synthase large subunit	0.91	0.60
14	ECD_02744		D-3-phosphoglycerate dehydrogenase	0.66	0.60
15	ECD_00056		4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent	0.93	0.60
16	ECD_01236		indole-3-glycerolphosphate synthetase and N-(5-phosphoribosyl)anthranilate isomerase	0.93	0.59
17	ECD_01058		dihydro-orotase	0.90	0.59
18	ECD_02254		chorismate synthase	0.79	0.58
19	ECD_04113		aspartate carbamoyltransferase, catalytic subunit	0.91	0.58
20	ECD_01924		histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase	0.83	0.58

Or look for negative cofitness