Top cofit genes for b4398 from Escherichia coli BW25113

creB: DNA-binding response regulator in two-component regulatory system with CreC (NCBI)
SEED: Two-component response regulator CreB
KEGG: two-component system, OmpR family, catabolic regulation response regulator CreB

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b4400	creD	inner membrane protein (NCBI)	0.52	0.42
2	b4399	creC	sensory histidine kinase in two-component regulatory system with CreB or PhoB, regulator of the CreBC regulon (NCBI)	0.61	0.38
3	b0196	rcsF	predicted outer membrane protein, signal (NCBI)	no	0.31
4	b2456	cchB	predicted carboxysome structural protein, ethanolamine utilization protein (NCBI)	no	0.29
5	b1056	yceI	hypothetical protein (NCBI)	0.38	0.29
6	b0389	yaiA	hypothetical protein (NCBI)	no	0.29
7	b3360	pabA	para-aminobenzoate synthase component II (NCBI)	0.34	0.29
8	b4006	purH	bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI)	no	0.29
9	b3220	yhcG	hypothetical protein (NCBI)	0.47	0.29
10	b4469	ygiQ	hypothetical protein (NCBI)	0.25	0.28
11	b1999	yeeP	putative histone (VIMSS)	no	0.28
12	b0033	carB	carbamoyl-phosphate synthase large subunit (NCBI)	no	0.28
13	b1062	pyrC	dihydroorotase (NCBI)	no	0.28
14	b1963	b1963	orf, hypothetical protein (VIMSS)	no	0.27
15	b2557	purL	phosphoribosylformylglycinamidine synthase (NCBI)	no	0.27
16	b0032	carA	carbamoyl-phosphate synthase small subunit (NCBI)	no	0.27
17	b4005	purD	phosphoribosylamine--glycine ligase (NCBI)	no	0.27
18	b4388	serB	3-phosphoserine phosphatase (NCBI)	0.49	0.27
19	b2750	cysC	adenylylsulfate kinase (NCBI)	no	0.27
20	b2499	purM	phosphoribosylaminoimidazole synthetase (NCBI)	no	0.27

Or look for negative cofitness