Top cofit genes for b4246 from Escherichia coli BW25113

pyrL: pyrBI operon leader peptide (NCBI)
SEED: PyrBI operon leader peptide

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b4245	pyrB	aspartate carbamoyltransferase catalytic subunit (NCBI)	no	0.60
2	b0033	carB	carbamoyl-phosphate synthase large subunit (NCBI)	no	0.58
3	b0945	pyrD	dihydroorotate dehydrogenase (NCBI)	no	0.58
4	b0032	carA	carbamoyl-phosphate synthase small subunit (NCBI)	no	0.58
5	b1062	pyrC	dihydroorotase (NCBI)	no	0.55
6	b1281	pyrF	orotidine 5'-phosphate decarboxylase (NCBI)	no	0.54
7	b3642	pyrE	orotate phosphoribosyltransferase (NCBI)	no	0.53
8	b0523	purE	phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI)	no	0.52
9	b4006	purH	bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI)	no	0.49
10	b2557	purL	phosphoribosylformylglycinamidine synthase (NCBI)	no	0.49
11	b2499	purM	phosphoribosylaminoimidazole synthetase (NCBI)	no	0.49
12	b2312	purF	amidophosphoribosyltransferase (NCBI)	no	0.49
13	b4005	purD	phosphoribosylamine--glycine ligase (NCBI)	no	0.48
14	b2476	purC	phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI)	no	0.48
15	b2839	lysR	DNA-binding transcriptional dual regulator (NCBI)	no	0.48
16	b0522	purK	phosphoribosylaminoimidazole carboxylase (NCBI)	no	0.48
17	b0002	thrA	bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI)	no	0.47
18	b0003	thrB	homoserine kinase (NCBI)	no	0.46
19	b3389	aroB	3-dehydroquinate synthase (NCBI)	no	0.46
20	b2913	serA	D-3-phosphoglycerate dehydrogenase (NCBI)	no	0.46

Or look for negative cofitness