Top cofit genes for b4015 from Escherichia coli BW25113

aceA: isocitrate lyase (NCBI)
SEED: Isocitrate lyase (EC 4.1.3.1)
KEGG: isocitrate lyase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b4014	aceB	malate synthase (NCBI)	0.94	0.53
2	b1702	pps	phosphoenolpyruvate synthase (NCBI)	0.91	0.46
3	b1896	otsA	trehalose-6-phosphate synthase (NCBI)	0.87	0.34
4	b2463	maeB	malic enzyme (NCBI)	0.86	0.31
5	b2790	yqcA	flavodoxin (NCBI)	0.14	0.28
6	b0722	sdhD	succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI)	0.29	0.25
7	b1836	yebV	orf, hypothetical protein (VIMSS)	no	0.25
8	b0724	sdhB	succinate dehydrogenase, FeS subunit (NCBI)	0.28	0.23
9	b2410	yfeH	predicted inner membrane protein (NCBI)	no	0.22
10	b0721	sdhC	succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI)	0.15	0.22
11	b4396	rob	DNA-binding transcriptional activator (NCBI)	no	0.22
12	b0723	sdhA	succinate dehydrogenase flavoprotein subunit (NCBI)	0.31	0.22
13	b1853	yebK	predicted DNA-binding transcriptional regulator (NCBI)	0.40	0.21
14	b0586	entF	enterobactin synthase multienzyme complex component, ATP-dependent (NCBI)	no	0.21
15	b1765	ydjA	predicted oxidoreductase (NCBI)	no	0.20
16	b0728	sucC	succinyl-CoA synthetase subunit beta (NCBI)	0.26	0.20
17	b3279	yrdA	putative transferase (VIMSS)	0.54	0.20
18	b1703	ydiA	hypothetical protein (NCBI)	0.42	0.19
19	b0390	aroM	hypothetical protein (NCBI)	no	0.19
20	b0198	metI	DL-methionine transporter subunit (NCBI)	no	0.19

Or look for negative cofitness