Top cofit genes for b4006 from Escherichia coli BW25113

purH: bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI)
SEED: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)
KEGG: phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b2557	purL	phosphoribosylformylglycinamidine synthase (NCBI)	0.99	0.98
2	b4005	purD	phosphoribosylamine--glycine ligase (NCBI)	0.98	0.98
3	b2312	purF	amidophosphoribosyltransferase (NCBI)	0.99	0.98
4	b2499	purM	phosphoribosylaminoimidazole synthetase (NCBI)	0.99	0.97
5	b0522	purK	phosphoribosylaminoimidazole carboxylase (NCBI)	0.98	0.96
6	b0523	purE	phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI)	0.99	0.95
7	b2476	purC	phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI)	0.98	0.94
8	b1062	pyrC	dihydroorotase (NCBI)	0.98	0.92
9	b0945	pyrD	dihydroorotate dehydrogenase (NCBI)	0.98	0.91
10	b1281	pyrF	orotidine 5'-phosphate decarboxylase (NCBI)	0.97	0.90
11	b3642	pyrE	orotate phosphoribosyltransferase (NCBI)	0.97	0.90
12	b4245	pyrB	aspartate carbamoyltransferase catalytic subunit (NCBI)	0.97	0.88
13	b0033	carB	carbamoyl-phosphate synthase large subunit (NCBI)	0.97	0.87
14	b4388	serB	3-phosphoserine phosphatase (NCBI)	0.92	0.87
15	b0032	carA	carbamoyl-phosphate synthase small subunit (NCBI)	0.95	0.86
16	b2329	aroC	chorismate synthase (NCBI)	0.93	0.86
17	b0907	serC	phosphoserine aminotransferase (NCBI)	0.84	0.86
18	b2913	serA	D-3-phosphoglycerate dehydrogenase (NCBI)	0.94	0.85
19	b0908	aroA	3-phosphoshikimate 1-carboxyvinyltransferase (NCBI)	0.95	0.85
20	b3389	aroB	3-dehydroquinate synthase (NCBI)	0.92	0.85

Or look for negative cofitness