Top cofit genes for b3828 from Escherichia coli BW25113

metR: DNA-binding transcriptional activator, homocysteine-binding (NCBI)
SEED: Transcriptional activator MetR
KEGG: LysR family transcriptional regulator, regulator for metE and metH

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b3829	metE	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI)	0.99	0.97
2	b0052	pdxA	4-hydroxythreonine-4-phosphate dehydrogenase (NCBI)	0.90	0.86
3	b2320	pdxB	erythronate-4-phosphate dehydrogenase (NCBI)	0.77	0.82
4	b2599	pheA	fused chorismate mutase P/prephenate dehydratase (NCBI)	0.99	0.82
5	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.99	0.81
6	b4214	cysQ	PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI)	0.97	0.81
7	b2838	lysA	diaminopimelate decarboxylase, PLP-binding (NCBI)	0.99	0.80
8	b1693	aroD	3-dehydroquinate dehydratase (NCBI)	0.95	0.80
9	b2022	hisB	imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS)	0.96	0.80
10	b2564	pdxJ	pyridoxal phosphate biosynthetic protein (NCBI)	0.77	0.79
11	b2023	hisH	imidazole glycerol phosphate synthase subunit HisH (NCBI)	0.98	0.79
12	b2025	hisF	imidazole glycerol phosphate synthase subunit HisF (NCBI)	0.97	0.79
13	b2020	hisD	histidinol dehydrogenase (NCBI)	0.98	0.79
14	b3172	argG	argininosuccinate synthase (NCBI)	0.97	0.78
15	b3960	argH	argininosuccinate lyase (NCBI)	0.97	0.78
16	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.99	0.78
17	b0075	leuL	leu operon leader peptide (NCBI)	0.41	0.78
18	b3774	ilvC	ketol-acid reductoisomerase (NCBI)	1.00	0.77
19	b2600	tyrA	fused chorismate mutase T/prephenate dehydrogenase (NCBI)	0.99	0.77
20	b3281	aroE	dehydroshikimate reductase, NAD(P)-binding (NCBI)	0.97	0.77

Or look for negative cofitness