Top cofit genes for b3642 from Escherichia coli BW25113

pyrE: orotate phosphoribosyltransferase (NCBI)
SEED: Orotate phosphoribosyltransferase (EC 2.4.2.10)
KEGG: orotate phosphoribosyltransferase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b0945	pyrD	dihydroorotate dehydrogenase (NCBI)	0.98	0.95
2	b1062	pyrC	dihydroorotase (NCBI)	0.98	0.95
3	b1281	pyrF	orotidine 5'-phosphate decarboxylase (NCBI)	0.97	0.94
4	b4245	pyrB	aspartate carbamoyltransferase catalytic subunit (NCBI)	0.99	0.91
5	b2557	purL	phosphoribosylformylglycinamidine synthase (NCBI)	0.97	0.90
6	b4006	purH	bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI)	0.97	0.90
7	b4005	purD	phosphoribosylamine--glycine ligase (NCBI)	0.96	0.90
8	b2499	purM	phosphoribosylaminoimidazole synthetase (NCBI)	0.97	0.89
9	b2312	purF	amidophosphoribosyltransferase (NCBI)	0.97	0.89
10	b0033	carB	carbamoyl-phosphate synthase large subunit (NCBI)	0.97	0.89
11	b0522	purK	phosphoribosylaminoimidazole carboxylase (NCBI)	0.96	0.89
12	b0523	purE	phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI)	0.95	0.88
13	b0032	carA	carbamoyl-phosphate synthase small subunit (NCBI)	0.97	0.88
14	b2476	purC	phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI)	0.95	0.87
15	b3389	aroB	3-dehydroquinate synthase (NCBI)	0.88	0.80
16	b3281	aroE	dehydroshikimate reductase, NAD(P)-binding (NCBI)	0.92	0.80
17	b2329	aroC	chorismate synthase (NCBI)	0.90	0.80
18	b2023	hisH	imidazole glycerol phosphate synthase subunit HisH (NCBI)	0.94	0.80
19	b0908	aroA	3-phosphoshikimate 1-carboxyvinyltransferase (NCBI)	0.92	0.80
20	b1693	aroD	3-dehydroquinate dehydratase (NCBI)	0.60	0.79

Or look for negative cofitness