Top cofit genes for b3281 from Escherichia coli BW25113

aroE: dehydroshikimate reductase, NAD(P)-binding (NCBI)
SEED: Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25)
KEGG: shikimate dehydrogenase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b3389	aroB	3-dehydroquinate synthase (NCBI)	0.98	0.99
2	b1693	aroD	3-dehydroquinate dehydratase (NCBI)	0.96	0.98
3	b0908	aroA	3-phosphoshikimate 1-carboxyvinyltransferase (NCBI)	0.96	0.95
4	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.94	0.95
5	b3774	ilvC	ketol-acid reductoisomerase (NCBI)	0.94	0.95
6	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.97	0.95
7	b3770	ilvE	branched-chain amino acid aminotransferase (NCBI)	0.97	0.94
8	b2600	tyrA	fused chorismate mutase T/prephenate dehydrogenase (NCBI)	0.93	0.94
9	b2329	aroC	chorismate synthase (NCBI)	0.95	0.93
10	b2022	hisB	imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS)	0.95	0.93
11	b2025	hisF	imidazole glycerol phosphate synthase subunit HisF (NCBI)	0.96	0.93
12	b2020	hisD	histidinol dehydrogenase (NCBI)	0.97	0.93
13	b1260	trpA	tryptophan synthase subunit alpha (NCBI)	0.96	0.93
14	b0072	leuC	isopropylmalate isomerase large subunit (NCBI)	0.97	0.93
15	b2021	hisC	histidinol-phosphate aminotransferase (NCBI)	0.97	0.93
16	b0073	leuB	3-isopropylmalate dehydrogenase (VIMSS)	0.96	0.93
17	b2838	lysA	diaminopimelate decarboxylase, PLP-binding (NCBI)	0.93	0.93
18	b3960	argH	argininosuccinate lyase (NCBI)	0.96	0.93
19	b0074	leuA	2-isopropylmalate synthase (NCBI)	0.98	0.92
20	b1261	trpB	tryptophan synthase subunit beta (NCBI)	0.96	0.92

Or look for negative cofitness