Top cofit genes for b2839 from Escherichia coli BW25113

lysR: DNA-binding transcriptional dual regulator (NCBI)
SEED: Transcriptional activator protein LysR

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b0002	thrA	bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI)	0.99	0.93
2	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.98	0.92
3	b2026	hisI	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI)	0.98	0.92
4	b3008	metC	cystathionine beta-lyase (NCBI)	0.98	0.92
5	b2750	cysC	adenylylsulfate kinase (NCBI)	0.98	0.92
6	b2019	hisG	ATP phosphoribosyltransferase (NCBI)	0.95	0.91
7	b2600	tyrA	fused chorismate mutase T/prephenate dehydrogenase (NCBI)	0.99	0.91
8	b2764	cysJ	sulfite reductase, alpha subunit, flavoprotein (NCBI)	0.98	0.91
9	b3960	argH	argininosuccinate lyase (NCBI)	0.99	0.91
10	b3770	ilvE	branched-chain amino acid aminotransferase (NCBI)	0.99	0.91
11	b2763	cysI	sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI)	0.98	0.91
12	b2414	cysK	cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI)	0.98	0.90
13	b3774	ilvC	ketol-acid reductoisomerase (NCBI)	0.98	0.90
14	b3772	ilvA	threonine dehydratase (NCBI)	0.99	0.90
15	b2020	hisD	histidinol dehydrogenase (NCBI)	0.94	0.90
16	b0072	leuC	isopropylmalate isomerase large subunit (NCBI)	0.97	0.90
17	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.97	0.90
18	b3368	cysG	fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI)	0.96	0.90
19	b1262	trpC	N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS)	0.92	0.90
20	b2762	cysH	phosphoadenosine phosphosulfate reductase (NCBI)	0.93	0.90

Or look for negative cofitness