Top cofit genes for b2499 from Escherichia coli BW25113

purM: phosphoribosylaminoimidazole synthetase (NCBI)
SEED: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
KEGG: phosphoribosylformylglycinamidine cyclo-ligase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b2557	purL	phosphoribosylformylglycinamidine synthase (NCBI)	0.99	0.98
2	b4005	purD	phosphoribosylamine--glycine ligase (NCBI)	0.99	0.97
3	b4006	purH	bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI)	0.99	0.97
4	b2312	purF	amidophosphoribosyltransferase (NCBI)	1.00	0.96
5	b0523	purE	phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI)	0.98	0.95
6	b0522	purK	phosphoribosylaminoimidazole carboxylase (NCBI)	0.98	0.95
7	b2476	purC	phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI)	0.99	0.94
8	b1062	pyrC	dihydroorotase (NCBI)	0.98	0.91
9	b0945	pyrD	dihydroorotate dehydrogenase (NCBI)	0.98	0.90
10	b1281	pyrF	orotidine 5'-phosphate decarboxylase (NCBI)	0.97	0.89
11	b3642	pyrE	orotate phosphoribosyltransferase (NCBI)	0.97	0.89
12	b4245	pyrB	aspartate carbamoyltransferase catalytic subunit (NCBI)	0.98	0.86
13	b4388	serB	3-phosphoserine phosphatase (NCBI)	0.91	0.85
14	b0033	carB	carbamoyl-phosphate synthase large subunit (NCBI)	0.96	0.85
15	b0032	carA	carbamoyl-phosphate synthase small subunit (NCBI)	0.96	0.85
16	b2913	serA	D-3-phosphoglycerate dehydrogenase (NCBI)	0.93	0.84
17	b2329	aroC	chorismate synthase (NCBI)	0.92	0.84
18	b0907	serC	phosphoserine aminotransferase (NCBI)	0.86	0.84
19	b0003	thrB	homoserine kinase (NCBI)	0.91	0.83
20	b0908	aroA	3-phosphoshikimate 1-carboxyvinyltransferase (NCBI)	0.93	0.83

Or look for negative cofitness