Top cofit genes for b2491 from Escherichia coli BW25113

hyfR: putative 2-component regulator, interaction with sigma 54 (VIMSS)
KEGG: hydrogenase-4 transcriptional activator

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b4314	fimA	major type 1 subunit fimbrin (pilin) (NCBI)	no	0.26
2	b0934	ycbM	putative transport system permease protein (VIMSS)	no	0.21
3	b3402	yhgE	predicted inner membrane protein (NCBI)	no	0.21
4	b3898	frvX	predicted endo-1,4-beta-glucanase (NCBI)	no	0.21
5	b2224	atoB	acetyl-CoA acetyltransferase (NCBI)	no	0.20
6	b1749	xthA	exonuclease III (NCBI)	no	0.19
7	b4317	fimD	outer membrane usher protein, type 1 fimbrial synthesis (NCBI)	no	0.18
8	b2983	yghQ	predicted inner membrane protein (NCBI)	no	0.18
9	b0756	galM	galactose-1-epimerase (mutarotase) (NCBI)	no	0.18
10	b4319	fimG	minor component of type 1 fimbriae (NCBI)	no	0.18
11	b3534	yhjQ	cell division protein (chromosome partitioning ATPase) (pseudogene) (RefSeq)	no	0.18
12	b0766	ybhA	predicted hydrolase (NCBI)	no	0.17
13	b2137	yohF	predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain (NCBI)	no	0.17
14	b0335	prpE	predicted propionyl-CoA synthetase with ATPase domain (NCBI)	no	0.17
15	b0845	ybjJ	predicted transporter (NCBI)	no	0.17
16	b4698	mgrR	sRNA antisense regulator down regulates YgdQ and EptB, PhoPQ-regulated, Hfq-dependent; affects sensitivity to antimicrobial peptides (RefSeq)	no	0.17
17	b4347	yjiW	conserved protein (RefSeq)	no	0.17
18	b4350	hsdR	endonuclease R (RefSeq)	no	0.17
19	b0186	ldcC	lysine decarboxylase 2, constitutive (NCBI)	0.77	0.17
20	b0155	clcA	chloride channel protein (NCBI)	no	0.17

Or look for negative cofitness