Top cofit genes for b2421 from Escherichia coli BW25113

cysM: cysteine synthase B (O-acetylserine sulfhydrolase B) (NCBI)
SEED: Cysteine synthase B (EC 2.5.1.47)
KEGG: cysteine synthase B

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b4256	yjgM	predicted acetyltransferase (NCBI)	0.58	0.30
2	b3867	hemN	O2-independent coproporphyrinogen III oxidase (VIMSS)	0.58	0.29
3	b2947	gshB	glutathione synthetase (NCBI)	0.70	0.28
4	b0197	metQ	DL-methionine transporter subunit (NCBI)	0.68	0.27
5	b1222	narX	sensory histidine kinase in two-component regulatory system with NarL (NCBI)	0.29	0.26
6	b2688	gshA	glutamate--cysteine ligase (NCBI)	0.75	0.26
7	b1256	ompW	outer membrane protein W (NCBI)	0.75	0.25
8	b4093	phnO	predicted acyltransferase with acyl-CoA N-acyltransferase domain (NCBI)	no	0.24
9	b4203	rplI	50S ribosomal protein L9 (NCBI)	no	0.24
10	b2945	endA	DNA-specific endonuclease I (NCBI)	no	0.24
11	b3068	ygjF	G/U mismatch-specific DNA glycosylase (NCBI)	0.34	0.24
12	b0611	rna	ribonuclease I (NCBI)	no	0.23
13	b2905	gcvT	glycine cleavage system aminomethyltransferase T (NCBI)	0.68	0.23
14	b2808	gcvA	DNA-binding transcriptional dual regulator (NCBI)	0.28	0.23
15	b0567	ybcH	hypothetical protein (NCBI)	no	0.23
16	b4190	yjfP	predicted hydrolase (NCBI)	0.42	0.23
17	b1236	galU	glucose-1-phosphate uridylyltransferase (NCBI)	0.75	0.22
18	b1685	ydiH	predicted protein (RefSeq)	no	0.22
19	b1187	fadR	fatty acid metabolism regulator (NCBI)	no	0.22
20	b2903	gcvP	glycine dehydrogenase (NCBI)	0.70	0.22

Or look for negative cofitness