Top cofit genes for b2312 from Escherichia coli BW25113

purF: amidophosphoribosyltransferase (NCBI)
SEED: Amidophosphoribosyltransferase (EC 2.4.2.14)
KEGG: amidophosphoribosyltransferase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b4005	purD	phosphoribosylamine--glycine ligase (NCBI)	1.00	0.98
2	b2557	purL	phosphoribosylformylglycinamidine synthase (NCBI)	0.99	0.98
3	b4006	purH	bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI)	0.99	0.98
4	b2499	purM	phosphoribosylaminoimidazole synthetase (NCBI)	1.00	0.96
5	b0522	purK	phosphoribosylaminoimidazole carboxylase (NCBI)	0.98	0.95
6	b0523	purE	phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI)	0.97	0.95
7	b2476	purC	phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI)	0.99	0.93
8	b1062	pyrC	dihydroorotase (NCBI)	0.98	0.90
9	b0945	pyrD	dihydroorotate dehydrogenase (NCBI)	0.97	0.90
10	b1281	pyrF	orotidine 5'-phosphate decarboxylase (NCBI)	0.96	0.89
11	b3642	pyrE	orotate phosphoribosyltransferase (NCBI)	0.97	0.89
12	b4245	pyrB	aspartate carbamoyltransferase catalytic subunit (NCBI)	0.97	0.86
13	b0033	carB	carbamoyl-phosphate synthase large subunit (NCBI)	0.97	0.85
14	b0032	carA	carbamoyl-phosphate synthase small subunit (NCBI)	0.95	0.85
15	b4388	serB	3-phosphoserine phosphatase (NCBI)	0.91	0.85
16	b2329	aroC	chorismate synthase (NCBI)	0.93	0.84
17	b0907	serC	phosphoserine aminotransferase (NCBI)	0.94	0.84
18	b0908	aroA	3-phosphoshikimate 1-carboxyvinyltransferase (NCBI)	0.94	0.83
19	b3389	aroB	3-dehydroquinate synthase (NCBI)	0.89	0.83
20	b2913	serA	D-3-phosphoglycerate dehydrogenase (NCBI)	0.94	0.83

Or look for negative cofitness